PubData is a search engine and file retrieval system for all bioinformatics databases worldwide. PubData searches biomedical FTP data in a user-friendly fashion similar to how PubMed searches biomedical literature. PubData is hosted as both a web application and a standalone graphical user interface (GUI) software program, while PubMed is hosted as an online web server. PubData is built on novel network programming and natural language processing algorithms that can patch into the FTP servers of any user-specified bioinformatics database, query its contents, and retrieve files for download. PubData is written in the Python programming language (specifically, Django and PyQt4). PubData can remotely search, access, view, and retrieve files from the deeply nested directory trees of any major bioinformatics database via a local computer network. By assembling all major bioinformatics databases under the roof of one software program, PubData allows the user to avoid the unnecessary hassle and non-standardized complexities inherent to accessing databases one-by-one using an Internet browser. More importantly, it allows a user to query multiple databases simultaneously for user-specified keywords (e.g., human, cancer, transcriptome). As such, PubData allows researchers to search, access, view, and download files from the FTP servers of any major bioinformatics database directly from one centralized location. By using only a GUI or web application, PubData allows the user to simultaneously surf multiple bioinformatics FTP servers directly from the comfort of their local computer.