pathpy is an OpenSource python package for the modeling and analysis of pathways and temporal networks using higher-order and multi-order graphical models. The package is specifically tailored to analyze sequential data which capture multiple observations of short, independent paths observed in an underlying graph topology. Examples for such data include user click streams in information networks, biological pathways, or traces of information propagating in social media. Unifying the analysis of pathways and temporal networks, pathpy also supports the extraction of time-respecting paths from time-stamped network data. It extends (and will eventually supersede) the package pyTempnets.