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SQLAlchemy is the Python SQL toolkit and Object Relational Mapper that gives application developers the full power and flexibility of SQL. It provides a full suite of well known enterprise-level persistence patterns, designed for efficient and high-performing database access, adapted into a simple and Pythonic domain language.
Spring is an Application framework which has Inversion of Control container, Aspect-oriented programming framework, Data access, Transaction management, Model-view-controller for web, Remote access framework (RPC) and lot more. It is well integrated with Toplink, Hibernate, JDO, and iBATIS.
Grails is an Open Source, full stack, web application framework for the JVM. It takes advantage of the Groovy programming language and convention over configuration to provide a productive and stream-lined development experience.