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DotNetOpenMail allows you to send email from applications which use Microsoft's .Net development framework, including asp.net, C# and WinForms. It is easy to create HTML and plain text email with file attachments without needing the System.Web.Mail library.
A programmer can use it to create multipart/alternative, multipart/related and multipart/mixed MIME messages in various character sets and various mime encodings such as quoted-printable, 7bit, 8bit and base64 without needing to know too much about the details.
Claws Mail is a GTK+ based, lightweight, and fast e-mail client and newsreader. Supports POP3, APOP, IMAP, SMTP, SMTP AUTH, NNTP, LDAP, multiple accounts, spell-checking, addressbook, SSL, GPG, filtering, i18n, & more. It is further extended by plugins. Lots of extra functionality, like an RSS aggregator, calendar, or laptop LED handling, are provided by extra plugins.
Roundcube Webmail is a browser-based multilingual IMAP client with an application-like user interface. It provides full functionality you expect from an email client, including MIME support, address book, folder management, message searching and spell checking.
Citadel is a collaboration suite (messaging and groupware). It provides support for Email, Calendaring/Scheduling, Address books, Bulletin boards, Mailing List Server, Instant Messaging, Wiki, Multiple domain support.
Gpg4win (GNU Privacy Guard for Windows) is encryption software for files and emails. Gpg4win supports both relevant cryptography standards, OpenPGP and S/MIME (X.509), and is the official GnuPG distribution for Windows. It is maintained by the developers of GnuPG.
OpenEMM is a feature-rich web-based enterprise application for email marketing, newsletters and service mails (transaction mails and event or time triggered mails). OpenEMM offers a great user interface, sophisticated bounce management, link tracking, lots of graphical realtime statistics, a CMS module and a scripting feature to implement individual tasks. OpenEMM is positioned at the intersection of E-Commerce, CRM, CMS, BI and ERP.
Zimbra is the most capable open source email and collaboration suite available today. It provides support for Email, Shared calendar, Document management, Pop3, Address book and lot more. Mails could be tagged and search support is also provided. Zimbra is considered as an alternative to Microsoft Exchange Server.
Clam AntiVirus is an anti-virus toolkit for UNIX, designed especially for e-mail scanning on mail gateways. It provides a number of utilities including a flexible and scalable multi-threaded daemon, a command line scanner and advanced tool for automatic database updates.
SharpWebMail is an ASP.NET webmail application that is written in C#. It uses a POP3 or IMAP servers as the mailstore and sends mail through a SMTP server. It is very simple to configure (only a few settings in the web.config file). You can compose HTML messages, search your inbox, read complex mime messages, have multiple address books and much more.
Sylpheed is a simple, lightweight but featureful, and easy-to-use e-mail client. It provides intuitive user-interface, Powerful filtering and search, Junk mail control, Security features (GnuPG, SSL/TLSv1). Sylpheed supports not only the major protocols such as POP3, IMAP4rev1 and SMTP, but also NNTP (NetNews). IPv6, which is the next-generation Internet protocol, is also supported by default.
Thunderbird is most popular simple e-mail, newsgroup and news feed client. It is comparable to Microsoft outlook. It supports features such as Firefox's tabbed browsing, Email search, Message archive, Spam filtering, Message grouping, SSL, TLS, POP3 and IMAP support and lot more.