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Mistakes are the portals of discovery. James Joyce (1882-1941) A metabolic network is defined as the set of biochemical reactions that the enzymes coded for in an organism's genome are capable of catalyzing. When the network of an organism is derived from pathway databases, it needs to be debugged for incoherences e.g., the metabolic model must obey mass balance laws. incompleteness e.g., the metabolic model is missing known reactions, genes, or compounds inconsistencies e.g., the metabolic mode