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Varnish Cache is a web application accelerator also known as a caching HTTP reverse proxy. You install it in front of any server that speaks HTTP and configure it to cache the contents. Varnish Cache is really, really fast. It typically speeds up delivery with a factor of 300 - 1000x, depending on your architecture.
Ehcache is an open source, standards-based cache used to boost performance, offload the database and simplify scalability. Ehcache is robust, proven and full-featured and this has made it the most widely-used Java-based cache.
Memcached is high-performance, distributed memory object caching system, generic in nature, but intended for use in speeding up dynamic web applications by alleviating database load. Memcached is an in-memory key-value store for small chunks of arbitrary data (strings, objects) from results of database calls, API calls, or page rendering.
Squid is a caching proxy for the Web supporting HTTP, HTTPS, FTP, and more. It reduces bandwidth and improves response times by caching and reusing frequently-requested web pages. Squid has extensive access controls and makes a great server accelerator. Cached content means data is served locally and users will see this through faster download speeds with frequently-used content.
Infinispan is an extremely scalable, highly available key/value NoSQL datastore and distributed data grid platform. The purpose of Infinispan is to expose a data structure that is highly concurrent, designed ground-up to make the most of modern multi-processor/multi-core architectures while at the same time providing distributed cache capabilities. Infinispan offers enterprise features such as efficient eviction algorithms to control memory usage as well as JTA compatibility.
Django is a high-level Python Web framework that encourages rapid development and clean, pragmatic design. Its feature include Admin site, Authentication, Internationalization, Jython support, Pagnition, Session management, Siemap, Feeds, Caching, Signals, Comments and lot more.
CakePHP makes building web applications simpler, faster and require less code. Its features include Database support, Application scaffolding, MVC architecture, Built-in validation, Data Sanitization, Flexible Caching, Localization, SQL injection prevention, Form tampering protection, Authentication and lot more.
nginx [engine x] is an HTTP and reverse proxy server, as well as a mail proxy server, written by Igor Sysoev. It supports accelerated reverse proxying with caching, simple load balancing and fault tolerance, SSL and TLS SNI support, Name-based and IP-based virtual servers and lot more.
CUBRID is a relational database management system highly optimized for Web Applications, especially when complex web services process large amount of data and generate huge concurrent requests. CUBRID is being developed in C/C++. Includes HA, online incremental backup, Replication, Load balancing, Sharding, Caching and other features. It supports JDBC, PHP, ODBC/.NET, Ruby & Python APIs.
Zend Server is a complete, enterprise-ready Web Application Server for running and managing PHP applications that require a high level of reliability, performance and security. It boosts application performane using byte code optimizer. It provides application stack for PHP application. It also provide support to connect to Java applications.